Olympus cellFRAP is designed with researchers in mind, providing highly accurate and flexible live-cell photomanipulation with various evaluation options for data presentation needs. cellFRAP employs a diffraction-limited laser spot for high-intensity and precise positioning of the bleaching region across the full field of view. The systems’ excellent spot quality allows full flexibility in position and shape of the bleaching region, and enables control of the bleaching area with extreme accuracy. Via incorporation into the Olympus IX3 open source frames, the cellFRAP deck can easily be adapted to an existing imaging platform with a full range of compatible accessories. Using the cellFRAP solution in the Olympus cellSens Graphical Experiment Manager provides simple system set-up and experiment control.