A unique camera, the DP80 combines both a color and a monochrome sensor within the same housing, providing high resolution brightfield imaging together with sensitive photon detection for fluorescent dyes. With versatile functionality, the cellSens control software enables rapid and automatic exchange between the chips, without manually switching the microscope optical path. Furthermore, the DP80 has the capacity to overlay images from the two sensors with accurate pixel-to-pixel correspondence, presenting significant opportunities for efficient and accurate joint color and fluorescent imaging, in both research and clinical environments.