This study was used to detect the insulin-like growth factor Binding Protein-1 (IGFBP-1) and fetal fibronectin (fFN) in vaginal secretions of pregnant women. Whether pregnant women have rupture of membranes (including premature rupture of membranes), as well as labor pregnancy (including preterm birth) prediction.

Insulin-like growth factor binding protein-1 (IGFBP-1) is one of the characteristic proteins of amniotic fluid. In normal pregnant women, the concentration of IGFBP-1 in amniotic fluid is 100 to 1000 times that of cervical secretions. After the exception, the content of IGFBP-1 in the cervical secretions increased sharply, reaching 400μg / L or more (95% of the premature rupture of membranes), so it was possible to judge whether the pregnant women had fetal membranes based on the IGFBP-1 content in pregnant women's cervical secretions rupture.

Fetal fibronectin (fFN) confined to the matrix structure of the parent and infant binding sites, fFN will increase in the normal pregnancy process, the first 22 weeks of gestational cervical secretions, but between 22 and 35 weeks, the cervical secretions In the fFN content is very small. Therefore, for 22 to 35 weeks of gestational age pregnant women, fFN increased with preterm birth, 95% of premature pregnant women, the cervical secretions in the fFN content of 1600μg / L or more.