Name: Pharma Extruders
Rating: 5 (34 reviews)

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First-class twin screw extruders for continuous mixing of pharmaceutical active ingredients
Coperion is pioneer in the development of high-end closely intermeshing, co-rotating twin screw extruders. We possess a unique know-how and an extraordinary wealth of experience in this continuous production process. Since the beginning of pharmaceutical extrusion we have continuously set new standards in the continuous manufacturing of pharmaceutical products with our special ZSK pharma extruders. This begins with special applications on a laboratory scale and extends right through to continuous pharmaceutical production systems.
SPECIAL FEATURES OF COPERION'S ZSK PHARMA EXTRUDERS
<ul>
<li>Modular barrel design with customized process length L/D to each individual product</li>
<li>Modular screw design with broad selection of screw elements for high process flexibility</li>
<li>Intensive mixing and dispersion of the twin screws for supreme product quality</li>
<li>Specific torque up to 18 Nm/cm³ allowing low ratios of throughput/rpm resulting in minimized product temperatures and API degradation</li>
<li>Manufactured in GMP design</li>
<li>All parts coming in contact with the product made of stainless steel with minimized surface roughness</li>
<li>Use of FDA-conformant oils/lubricants</li>
<li>Complete documentation of all process parameters (V-lifecycle) based on URS (User requirement specification)</li>
<li>Compact design and therefore low space requirement</li>
<li>Self-cleaning of the twin screws avoids dead spaces and results in short residence times</li>
<li>Clear arrangement of the extruder with easy operation, easy access for cleaning and maintenance</li>
<li>Simple handling and quick dismantling using quick release couplings</li>
<li>PLC and visualisation system conform to CFR Part 11</li>
<li>FAT (factory acceptance test) and SAT (site acceptance test)</li>
<li>Reliable scale-up due to geometrical constancy within the ZSK series</li>
<li>Professional process engineering support with know-how from over 30 years of experience in pharmaceutical applications</li>
<li>Comprehensive after-sales services by worldwide Coperion service network</li>
</ul>
TYPICAL AREAS OF APPLICATION OF COPERION'S PHARMA EXTRUDERS
<ul>
<li>Pharmaceutical Hot Melt Extrusion
<ul>
<li>Solvent-free production of solid dispersions or solids solutions of APIs ( also BCS class 2 & 4), thus enhancing their bioavailability</li>
<li>Hot Melt extrudates as basis for solid dosage forms with controlled / sustained release of APIs</li>
<li>Degassing of water to counteract API re-crystallisation</li>
<li>Encapsulation and taste masking</li>
</ul>
</li>
</ul>
<ul>
<li>Wet Extrusion of  APIs as basis for granules for capsule filling</li>
<li>Extrusion of adhesives with APIs for transdermal plasters</li>
<li>Extrusion of adhesives for medical applications such as stoma</li>
<li>Extrusion of compounds for implants/biodegradable implants or contraceptive rings</li>
<li>Extrusion of medical plastics (wound plasters/butterfly closures)</li>
</ul>
TECHNICAL DATA
<table>
<tr>
<td>ZSK</td>
<td>Max. torque per shaft [Nm]</td>
<td>Specific torque Md/a³ [Nm/cm³]</td>
<td>Max. screw speed [min-1]</td>
<td>Max. motor power N [kW]</td>
<td>Screw diameter [mm]</td>
</tr>
<tr>
<td>18 MEGAlab*</td>
<td>38</td>
<td>11.3</td>
<td>1,200</td>
<td>10</td>
<td>18</td>
</tr>
<tr>
<td>26</td>
<td>140</td>
<td>15</td>
<td>1,200</td>
<td>37</td>
<td>25</td>
</tr>
<tr>
<td>32</td>
<td>315</td>
<td>18</td>
<td>1,200</td>
<td>83</td>
<td>32</td>
</tr>
<tr>
<td>40</td>
<td>510</td>
<td>13.6</td>
<td>1,200</td>
<td>135</td>
<td>40</td>
</tr>
<tr>
<td>70</td>
<td>3,500</td>
<td>18</td>
<td>1,200</td>
<td>924</td>
<td>70</td>
</tr>
</table>
* Laboratory extruder
LABORATORY EXTRUDER ZSK 18 MEGALAB
Highest performance even for smallest batch sizes. Modular construction, GMP design, maximum speed, highest power density, safe scale-up, tailor-made controls – the ZSK 18 MEGAlab laboratory extruder is the smallest member of the ZSK family. This targeted and further development of proven ZSK technology extends the performance range of the series for R&D and production of pharmaceutical materials in a minimum quantity range.
<ul>
<li>Md / a3 = 11.3 Nm/cm3</li>
<li>Do / Di = 1.55</li>
<li>Maximum speed = 1,200 rpm</li>
<li>Maximum length of process section = 15 barrels (60 D)</li>
<li>Throughput rates between 1 and 10 kg/h</li>
<li>Quick plug & play commissioning</li>
<li>Reliable, low noise drive concept</li>
<li>Modular construction with exchangeable 4D barrels and all standard screw elements</li>
<li>Flight depth of 3.2 mm enables pellet feeding</li>
<li>Simple to operate via PLC control and touch screen</li>
<li>Compact size – mobile stainless steel base frame with integrated controls and water cooling system with option for direct mounting of a Coperion K-tron solid feeder</li>
<li>Proven scale-up due to geometrical constancy within the ZSK series</li>
</ul>

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Member since : 15-Jan-2017

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Plastic Extruders

Pharma Extruders

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Min Order : 100
Condition : New
Warranty: : YES
Country of shipping : Germany

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Item Details

Product Specification

Condition	New
Warranty	YES
Fuel Type	Gasoline

Product Descriptions

First-class twin screw extruders for continuous mixing of pharmaceutical active ingredients

Coperion is pioneer in the development of high-end closely intermeshing, co-rotating twin screw extruders. We possess a unique know-how and an extraordinary wealth of experience in this continuous production process. Since the beginning of pharmaceutical extrusion we have continuously set new standards in the continuous manufacturing of pharmaceutical products with our special ZSK pharma extruders. This begins with special applications on a laboratory scale and extends right through to continuous pharmaceutical production systems.

SPECIAL FEATURES OF COPERION'S ZSK PHARMA EXTRUDERS

Modular barrel design with customized process length L/D to each individual product
Modular screw design with broad selection of screw elements for high process flexibility
Intensive mixing and dispersion of the twin screws for supreme product quality
Specific torque up to 18 Nm/cm³ allowing low ratios of throughput/rpm resulting in minimized product temperatures and API degradation
Manufactured in GMP design
All parts coming in contact with the product made of stainless steel with minimized surface roughness
Use of FDA-conformant oils/lubricants
Complete documentation of all process parameters (V-lifecycle) based on URS (User requirement specification)
Compact design and therefore low space requirement
Self-cleaning of the twin screws avoids dead spaces and results in short residence times
Clear arrangement of the extruder with easy operation, easy access for cleaning and maintenance
Simple handling and quick dismantling using quick release couplings
PLC and visualisation system conform to CFR Part 11
FAT (factory acceptance test) and SAT (site acceptance test)
Reliable scale-up due to geometrical constancy within the ZSK series
Professional process engineering support with know-how from over 30 years of experience in pharmaceutical applications
Comprehensive after-sales services by worldwide Coperion service network

TYPICAL AREAS OF APPLICATION OF COPERION'S PHARMA EXTRUDERS

Pharmaceutical Hot Melt Extrusion
- Solvent-free production of solid dispersions or solids solutions of APIs ( also BCS class 2 & 4), thus enhancing their bioavailability
- Hot Melt extrudates as basis for solid dosage forms with controlled / sustained release of APIs
- Degassing of water to counteract API re-crystallisation
- Encapsulation and taste masking

Wet Extrusion of APIs as basis for granules for capsule filling
Extrusion of adhesives with APIs for transdermal plasters
Extrusion of adhesives for medical applications such as stoma
Extrusion of compounds for implants/biodegradable implants or contraceptive rings
Extrusion of medical plastics (wound plasters/butterfly closures)

TECHNICAL DATA

ZSK	Max. torque per shaft [Nm]	Specific torque Md/a³ [Nm/cm³]	Max. screw speed [min-1]	Max. motor power N [kW]	Screw diameter [mm]
18 MEGAlab*	38	11.3	1,200	10	18
26	140	15	1,200	37	25
32	315	18	1,200	83	32
40	510	13.6	1,200	135	40
70	3,500	18	1,200	924	70

* Laboratory extruder

LABORATORY EXTRUDER ZSK 18 MEGALAB

Highest performance even for smallest batch sizes. Modular construction, GMP design, maximum speed, highest power density, safe scale-up, tailor-made controls – the ZSK 18 MEGAlab laboratory extruder is the smallest member of the ZSK family. This targeted and further development of proven ZSK technology extends the performance range of the series for R&D and production of pharmaceutical materials in a minimum quantity range.

Md / a3 = 11.3 Nm/cm3
Do / Di = 1.55
Maximum speed = 1,200 rpm
Maximum length of process section = 15 barrels (60 D)
Throughput rates between 1 and 10 kg/h
Quick plug & play commissioning
Reliable, low noise drive concept
Modular construction with exchangeable 4D barrels and all standard screw elements
Flight depth of 3.2 mm enables pellet feeding
Simple to operate via PLC control and touch screen
Compact size – mobile stainless steel base frame with integrated controls and water cooling system with option for direct mounting of a Coperion K-tron solid feeder
Proven scale-up due to geometrical constancy within the ZSK series